Ischemic stroke is a general term for necrosis of brain tissue caused by insufficient blood supply to the brain due to stenosis or occlusion of the arteries supplying blood to the brain (carotid and vertebral arteries) ( Herpich and Rincon, 2020). It accounts for about 70% of all acute cerebrovascular diseases, mainly in the middle-aged and elderly groups. Ischemic stroke, also known as cerebral infarction, is the most common type of cerebrovascular disease. Based on their potential and challenges in the treatment of ischemic stroke, new ideas and prospects are proposed for designing feasible and effective nano delivery systems. In this review, we first introduced several ways of nano delivery systems crossing the BBB, and then summarized their applications in ischemic stroke. At present, the materials used in brain-targeted delivery can be divided into natural polymer, synthetic polymers, inorganic materials and phospholipid. The main pathways of nano delivery systems through BBB include passive diffusion, adsorption-mediated endocytosis, receptor-mediated transport, carrier-mediated transport, etc. Nanoparticles are a good choice for drugs to cross BBB. Therefore, effective treatment requires the better drug transport across membranes and increased drug distribution. The blood-brain barrier (BBB) protects the homeostasis of the brain’s microenvironment and impedes the penetration of 98% of drugs. Ischemic stroke is the most common type of cerebrovascular disease with high disability rate and mortality. 2Department of Pharmacy, Ningbo University Affiliated Yangming Hospital, Yuyao, China.1Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo, China. Yi-Xuan Li 1 Hong-Bo Wang 2 Jian-Bo Jin 2 Chun-Lin Yang 2 Jing-Bo Hu 1 Jing Li 2*
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